eGFR Creatinine Based Formula Calculator

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The eGFR Creatinine Based Formula?

The eGFR Creatinine Based Formula using CKD-EPI 2021 estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy for kidney function assessment compared to previous versions.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The equation accounts for non-linear relationship between creatinine and GFR, with optimized coefficients for different demographic groups based on the 2021 update.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What's New In The CKD-EPI 2021 Equation?
A: The 2021 version features updated coefficients (142, -1.200, 0.9938) and gender factors (1.012) for improved accuracy across diverse populations.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² for 3+ months indicate chronic kidney disease.

Q3: When Should Creatinine Be Measured?
A: Morning fasting samples are preferred, but random samples are acceptable. Avoid testing after high-protein meals or intense physical activity.

Q4: Are There Limitations To This Equation?
A: This equation may be less accurate in extreme age groups, pregnant women, individuals with amputations, or those with rapidly changing kidney function.

Q5: Can This Be Used For Drug Dosing?
A: While useful for screening, precise drug dosing may require measured GFR in specific clinical situations or high-risk populations.