eGFR Crea CKD EPI Calculator

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the eGFR Crea CKD EPI Calculator?

The eGFR Crea CKD EPI Calculator estimates glomerular filtration rate (GFR) using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation based on serum creatinine, age, and gender. This calculator provides an accurate assessment of kidney function for clinical evaluation.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation accounts for the non-linear relationship between serum creatinine and glomerular filtration rate, with optimized coefficients for different demographic groups to provide more accurate kidney function estimation.

3. Importance of eGFR Calculation

Details: Accurate estimation of glomerular filtration rate is essential for diagnosing chronic kidney disease, determining the stage of kidney impairment, monitoring disease progression, and guiding appropriate medication dosing for patients with renal impairment.

4. Using the Calculator

Tips: Enter serum creatinine value in mg/dL, age in years, and select gender. Ensure all values are valid (serum creatinine > 0, age between 1-120 years). The calculator will provide the estimated GFR in mL/min/1.73m².

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between this equation and other GFR equations?
A: This CKD-EPI equation provides more accurate estimates at higher GFR levels compared to older equations like MDRD, with better precision across the full range of kidney function.

Q2: What are the reference ranges for eGFR?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild reduction, while persistent values below 60 mL/min/1.73m² for 3+ months suggest chronic kidney disease.

Q3: When is the best time to measure serum creatinine?
A: Morning fasting samples are preferred, though random samples are acceptable. Avoid testing shortly after high-protein meals or intense physical activity as these can temporarily elevate creatinine levels.

Q4: What are the limitations of this equation?
A: The equation may be less accurate in extreme age groups, amputees, pregnant women, individuals with unusual body composition, and those with rapidly changing kidney function.

Q5: Can this calculator be used for medication dosing?
A: While useful for clinical assessment, for precise drug dosing in critical situations, measured GFR (using methods like iohexol clearance) may be necessary, especially in populations where estimation equations are less accurate.