eGFR Calculator UK

UK CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the UK CKD-EPI 2021 Equation?

The UK CKD-EPI 2021 equation is an updated version of the CKD-EPI formula specifically calibrated for the UK population. It estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex, providing improved accuracy for kidney function assessment in the UK demographic.

2. How Does the Calculator Work?

The calculator uses the UK CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is optimized for the UK population and provides more accurate GFR estimates compared to the standard CKD-EPI equation in this demographic.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management in the UK healthcare system.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator is specifically designed for use with UK population data.

5. Frequently Asked Questions (FAQ)

Q1: Why use the UK CKD-EPI 2021 instead of standard CKD-EPI?
A: The UK version is specifically calibrated for the UK population, providing more accurate results for this demographic group.

Q2: What are the key differences from standard CKD-EPI?
A: Different coefficients (142 vs 141), different exponents (-1.200 vs -1.209), age factor (0.9938 vs 0.993), and female multiplier (1.012 vs 1.018).

Q3: Is race factor used in the UK equation?
A: No, the UK CKD-EPI 2021 equation does not include a race factor, aligning with current UK clinical guidelines.

Q4: When was this equation introduced?
A: The UK CKD-EPI 2021 equation was introduced in 2021 as an update to better serve the UK population.

Q5: Is this calculator suitable for all UK patients?
A: While optimized for the UK population, clinical judgment should always be used, especially for patients with unusual body composition or other special circumstances.