eGFR Calculator UK NHS

UK NHS CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the UK NHS CKD-EPI 2021 Equation?

The UK NHS CKD-EPI 2021 equation is an updated version of the CKD-EPI formula used by the UK National Health Service to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version provides enhanced accuracy for the UK population.

2. How Does the Calculator Work?

The calculator uses the UK NHS CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation represents the latest UK NHS adaptation with updated coefficients optimized for the UK population demographics.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for detecting chronic kidney disease, monitoring kidney function, and adjusting medication dosages according to UK NHS guidelines.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator follows UK NHS 2021 standards.

5. Frequently Asked Questions (FAQ)

Q1: Why does the UK NHS use this specific equation?
A: The UK NHS CKD-EPI 2021 equation has been validated and calibrated specifically for the UK population to provide more accurate results for local demographics.

Q2: How does this differ from standard CKD-EPI?
A: This version uses updated coefficients (142, -1.200, 0.9938, 1.012) optimized for UK population data and follows 2021 NHS guidelines.

Q3: What are the UK NHS reference ranges for eGFR?
A: Normal eGFR is ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² for 3+ months indicate chronic kidney disease according to UK guidelines.

Q4: Is race factor included in UK NHS calculation?
A: No, the UK NHS 2021 equation does not include race as a factor, following updated guidelines that avoid race-based adjustments.

Q5: When should this calculator be used in clinical practice?
A: This calculator is designed for use in UK healthcare settings following NHS 2021 guidelines for initial kidney function assessment.