eGFR Calculator UK Liverpool

UK Liverpool eGFR calculator using CKD-EPI 2021:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the UK Liverpool eGFR Calculator?

The UK Liverpool eGFR calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version is specifically calibrated for the UK population and provides accurate assessment of kidney function.

2. How Does the Calculator Work?

The calculator uses the UK Liverpool CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for the UK population and accounts for non-linear relationship between creatinine and GFR with updated coefficients.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing in the UK healthcare system.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: Why use the UK Liverpool version of CKD-EPI?
A: This version is specifically calibrated for the UK population and provides more accurate results for patients in the UK healthcare system.

Q2: What are normal eGFR values for UK population?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.

Q3: When should creatinine be measured?
A: Morning fasting sample is ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Should this be used for drug dosing?
A: For precise drug dosing in complex cases, measured GFR may be needed, but this calculator provides reliable estimates for most clinical purposes.