eGFR Calculator New

New eGFR calculator (2021 CKD-EPI):

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the New eGFR Calculator (2021 CKD-EPI)?

The 2021 CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation is an updated version that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This newer equation provides improved accuracy and eliminates race as a variable, focusing on biological factors only.

2. How Does the Calculator Work?

The calculator uses the 2021 CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This updated equation uses refined coefficients and eliminates race adjustment, providing a more universally applicable GFR estimation.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, determining appropriate medication dosages, and assessing overall kidney health.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). The calculator uses the latest 2021 CKD-EPI equation without race adjustment.

5. Frequently Asked Questions (FAQ)

Q1: What's new in the 2021 CKD-EPI equation?
A: The 2021 version uses updated coefficients and eliminates race as a variable, providing a more equitable and accurate GFR estimation across all populations.

Q2: Why was race removed from the equation?
A: Race was removed to eliminate potential health disparities and provide more biologically-based GFR estimates that are applicable to all individuals regardless of race.

Q3: What are normal eGFR values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² for 3+ months typically indicate chronic kidney disease.

Q4: How does this compare to the older CKD-EPI equation?
A: The 2021 equation provides similar accuracy but with updated coefficients and no race adjustment, making it more equitable while maintaining clinical utility.

Q5: Are there limitations to this equation?
A: As with all estimation equations, it may be less accurate in extremes of age, body composition, pregnant women, and those with rapidly changing kidney function.