eGFR Calculator National Kidney Foundation Malaysia

NKF Malaysia eGFR using CKD-EPI 2021

NKF Malaysia CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the NKF Malaysia CKD-EPI 2021 Equation?

The NKF Malaysia CKD-EPI 2021 equation is a modified version of the CKD-EPI equation specifically validated for the Malaysian population. It estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex, providing accurate assessment of kidney function for local demographic characteristics.

2. How Does the Calculator Work?

The calculator uses the NKF Malaysia CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for the Malaysian population and accounts for non-linear relationship between creatinine and GFR with optimized coefficients for local demographics.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease in the Malaysian population, determining disease stage according to local guidelines, and guiding appropriate medication dosing and treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator is specifically validated for use in Malaysian clinical practice.

5. Frequently Asked Questions (FAQ)

Q1: Why use NKF Malaysia CKD-EPI 2021 instead of standard CKD-EPI?
A: This equation is specifically validated and calibrated for the Malaysian population, providing more accurate results for local demographic and genetic characteristics.

Q2: What are normal eGFR values for Malaysian population?
A: Normal is generally ≥90 mL/min/1.73m², though values may vary based on age and other factors. Below 60 for 3+ months indicates CKD according to Malaysian guidelines.

Q3: When should creatinine be measured in Malaysian clinical practice?
A: Morning fasting sample is recommended. Consider local dietary patterns and ensure proper calibration of laboratory equipment according to Malaysian standards.

Q4: Are there limitations to this equation in Malaysia?
A: As with all estimation equations, caution is needed in extremes of age, amputees, pregnant women, and those with rapidly changing kidney function or unusual muscle mass.

Q5: Is this equation accepted by Malaysian health authorities?
A: Yes, the NKF Malaysia CKD-EPI 2021 equation is recommended by the National Kidney Foundation of Malaysia for use in local clinical practice.