eGFR Calculator NHS UK

NHS UK eGFR using CKD-EPI 2021:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the NHS UK eGFR Calculator?

The NHS UK eGFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version is specifically adapted for use in the UK National Health Service and provides accurate assessment of kidney function.

2. How Does the Calculator Work?

The calculator uses the NHS UK CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( Age \) — Age in years
1.012 — Female multiplier

Explanation: This equation represents the updated CKD-EPI formula used by NHS UK in 2021, with optimized coefficients for the UK population.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for detecting chronic kidney disease, monitoring disease progression, and guiding clinical decisions in the UK healthcare system.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator follows NHS UK guidelines.

5. Frequently Asked Questions (FAQ)

Q1: What makes the NHS UK version different?
A: The NHS UK version uses updated coefficients (142, -1.200, 0.9938) specifically validated for the UK population and removes the race factor used in some other versions.

Q2: What are the NHS UK reference ranges for eGFR?
A: Normal is ≥90 mL/min/1.73m². Values between 60-89 may indicate early kidney disease. Below 60 for 3+ months indicates chronic kidney disease.

Q3: How often should eGFR be monitored?
A: According to NHS guidelines, frequency depends on risk factors and existing conditions. Annual testing is recommended for high-risk individuals.

Q4: Are there limitations to this equation?
A: Like all estimating equations, it may be less accurate in extremes of age, body composition, or in populations with unusual muscle mass.

Q5: Is this calculator suitable for clinical use?
A: This calculator follows NHS UK algorithms but should be used in conjunction with clinical assessment by healthcare professionals.