1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — Black race multiplier

Explanation: The equation uses serum creatinine, age, gender, and race to estimate glomerular filtration rate, which reflects kidney function.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on kidney function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate in patients with established CKD, while CKD-EPI performs better at higher GFR levels and is less likely to misclassify individuals with normal or mildly reduced kidney function.

Q2: What are the limitations of the MDRD equation?
A: The equation may be less accurate in elderly patients, those with normal kidney function, and populations with extreme body composition.

Q3: When should the MDRD equation be used?
A: MDRD is commonly used in clinical practice for patients with known or suspected chronic kidney disease.

Q4: How does age affect eGFR calculation?
A: GFR naturally declines with age, which is accounted for in the equation through the age component.

Q5: Why are different factors used for different races?
A: Race factors account for differences in muscle mass and creatinine production among different ethnic groups.