eGFR Calculator Kidney Foundation

Kidney Foundation eGFR using CKD-EPI 2021:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is the Kidney Foundation eGFR Calculator?

The Kidney Foundation eGFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in assessing kidney function across diverse populations.

2. How Does the Calculator Work?

The calculator uses the Kidney Foundation CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation represents the latest refinement of the CKD-EPI formula with updated coefficients for improved accuracy in GFR estimation.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What's new in the 2021 CKD-EPI equation?
A: The 2021 version features updated coefficients (142, -1.200, 0.9938) and gender-specific parameters for improved accuracy across different populations.

Q2: How does this differ from previous CKD-EPI equations?
A: This version uses refined mathematical coefficients and removes race adjustment, focusing on creatinine, age, and sex only.

Q3: What are the clinical applications of this calculator?
A: Used for screening, diagnosis, and monitoring of chronic kidney disease, as well as drug dosing adjustments in patients with renal impairment.

Q4: Are there limitations to this equation?
A: Like all estimating equations, it may be less accurate in extremes of age, body composition, or in populations with rapidly changing kidney function.

Q5: When should confirmatory testing be considered?
A: When eGFR results are borderline, inconsistent with clinical presentation, or when precise GFR measurement is required for treatment decisions.