eGFR Calculator India

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI 2021 Equation?

The CKD-EPI 2021 equation is a modified version specifically validated for the Indian population that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. It provides more accurate kidney function assessment for Indian patients compared to standard equations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for the Indian population and accounts for demographic variations in creatinine metabolism and muscle mass.

3. Importance of eGFR Calculation in India

Details: Accurate GFR estimation is crucial in India due to the high prevalence of diabetes and hypertension, which are major risk factors for chronic kidney disease. Population-specific equations provide better clinical decision making.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). Use fasting serum creatinine values for optimal accuracy.

5. Frequently Asked Questions (FAQ)

Q1: Why use CKD-EPI 2021 for Indian population?
A: This equation is specifically validated for Indian patients and accounts for ethnic variations in creatinine production and metabolism.

Q2: What are normal eGFR values for Indians?
A: Normal is generally ≥90 mL/min/1.73m², though values may vary based on age, diet, and regional factors.

Q3: Are there regional variations in India?
A: Yes, dietary patterns and genetic factors may cause slight regional variations in creatinine levels and GFR estimates.

Q4: How does this compare to standard CKD-EPI?
A: The 2021 version uses different coefficients (142 vs 141, different exponents) optimized for Indian demographic characteristics.

Q5: Should this be used for all Indian ethnic groups?
A: While validated for the general Indian population, further validation may be needed for specific ethnic subgroups.