eGFR Calculator EPI CKD

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI eGFR Calculator?

The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) eGFR calculator estimates glomerular filtration rate using an advanced equation that provides accurate assessment of kidney function across different population groups.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation provides a more precise estimation of glomerular filtration rate by accounting for the non-linear relationship between serum creatinine and kidney function.

3. Importance of eGFR Calculation

Details: Accurate eGFR calculation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management and treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid with creatinine greater than 0 and age between 1-120 years for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What makes this CKD-EPI equation different?
A: This version uses updated coefficients (142, -1.200, 0.9938) that provide enhanced accuracy in estimating glomerular filtration rate across diverse populations.

Q2: What are the clinical implications of eGFR results?
A: eGFR values help classify kidney disease stages: ≥90 (normal), 60-89 (mild reduction), 30-59 (moderate), 15-29 (severe), and <15 (kidney failure).

Q3: How often should eGFR be monitored?
A: Frequency depends on clinical context - annually for at-risk individuals, more frequently for those with established kidney disease or during treatment changes.

Q4: Are there factors that can affect eGFR accuracy?
A: Yes, factors include muscle mass extremes, dietary protein intake, certain medications, and conditions affecting creatinine production or secretion.

Q5: When should additional kidney function tests be considered?
A: Additional tests like cystatin C or measured GFR may be needed when creatinine-based estimates are unreliable due to unusual body composition or diet.