1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — Black race multiplier

Explanation: The equation uses serum creatinine, age, gender, and race to estimate kidney function, with different coefficients for different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, determining disease stage, monitoring progression, and guiding medication dosing decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: CKD-EPI is generally more accurate at higher GFR levels (>60 mL/min/1.73m²), while MDRD may be more accurate in advanced CKD patients.

Q2: What are the limitations of the MDRD equation?
A: Less accurate in elderly patients, extremes of body size, pregnant women, and populations with normal or near-normal kidney function.

Q3: When is MDRD preferred over CKD-EPI?
A: MDRD may be preferred in specific clinical settings or when comparing with historical data that used MDRD calculations.

Q4: How often should eGFR be monitored?
A: Frequency depends on clinical context - from every 3-12 months in stable CKD to more frequently during acute illness or medication changes.

Q5: Can this calculator be used for children?
A: No, the MDRD equation is validated for adults only. Pediatric patients require age-appropriate GFR estimation equations.