eGFR Calculator CKD EPI Calculator

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The eGFR Calculator CKD EPI Calculator?

The eGFR Calculator CKD EPI Calculator estimates glomerular filtration rate (GFR) using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation based on serum creatinine, age, and gender. It provides accurate assessment of kidney function for clinical evaluation.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( eGFR \) — Estimated glomerular filtration rate (mL/min/1.73m²)
\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 if female, 0.9 if male (unitless)
\( \alpha \) — -0.241 if female, -0.302 if male (unitless)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation provides a more accurate estimation of kidney function across different demographic groups, accounting for the non-linear relationship between serum creatinine and GFR.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, determining appropriate treatment strategies, and adjusting medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years). Use recent laboratory results for accurate calculations.

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between This Equation And Standard CKD-EPI?
A: This version uses specific coefficients (142, -1.200, 0.9938) and gender factor (1.012) optimized for particular populations or study cohorts.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild reduction, while values below 60 for 3+ months suggest chronic kidney disease.

Q3: When Should Serum Creatinine Be Measured?
A: Morning fasting samples are preferred, but random samples are acceptable. Avoid testing shortly after high-protein meals or intense physical activity.

Q4: Are There Limitations To This Equation?
A: This equation may be less accurate in elderly patients, extremes of body size, amputees, pregnant women, and individuals with rapidly changing kidney function or muscle mass.

Q5: Can This Calculator Be Used For Drug Dosing?
A: While useful for initial assessment, precise drug dosing in critical situations may require measured GFR or consultation with a clinical pharmacist.