eGFR Calculation Formula UK

UK eGFR Formula Using CKD-EPI 2021:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the UK eGFR Formula Using CKD-EPI 2021?

The UK eGFR formula using CKD-EPI 2021 is an updated equation for estimating glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version incorporates refinements to improve accuracy in the UK population and represents the latest standard for kidney function assessment.

2. How Does the Calculator Work?

The calculator uses the UK CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This updated equation provides improved accuracy for GFR estimation in the UK population with optimized coefficients and exponents.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management and treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What's different about the UK CKD-EPI 2021 formula?
A: This version includes updated coefficients (142 instead of 141, different alpha values, and 0.9938 instead of 0.993) optimized for the UK population.

Q2: Why was the formula updated?
A: The update reflects population-specific data and aims to improve accuracy in GFR estimation for UK patients, reducing misclassification.

Q3: Is race still a factor in this equation?
A: No, the UK 2021 version removes race as a factor, focusing only on serum creatinine, age, and gender.

Q4: How does this compare to the original CKD-EPI?
A: This version provides similar accuracy but with coefficients specifically calibrated for the UK population and contemporary clinical practice.

Q5: When should this formula be used?
A: This is the recommended formula for eGFR calculation in UK clinical practice for adults with stable kidney function.