eGFR Calculation EPI Method

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the eGFR Calculation EPI Method?

The eGFR Calculation EPI Method estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex using the CKD-EPI equation. It provides an accurate assessment of kidney function for clinical evaluation and monitoring.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The equation accounts for the non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, monitoring kidney function over time, and guiding appropriate clinical management decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years). Ensure accurate laboratory values for precise results.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between this equation and other eGFR formulas?
A: This specific EPI method uses coefficients of 142, -1.200, and 0.9938 with gender-specific α values, providing optimized accuracy for general population screening.

Q2: What are the clinical implications of eGFR results?
A: eGFR values help classify kidney disease stages: ≥90 (normal), 60-89 (mild reduction), 30-59 (moderate), 15-29 (severe), <15 (kidney failure).

Q3: How often should eGFR be monitored?
A: Frequency depends on clinical context - annually for at-risk patients, more frequently for those with established kidney disease or changing clinical status.

Q4: Are there patient populations where this equation may be less accurate?
A: Accuracy may be reduced in extremes of age, amputees, severe malnutrition, obesity, rapidly changing kidney function, and certain ethnic populations.

Q5: Can this calculator be used for pediatric patients?
A: No, this equation is validated for adults (≥18 years). Pediatric patients require age and height-adjusted formulas like the Schwartz equation.