eGFR Calculation Asian

Modified CKD-EPI Equation for Asian Population:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times 0.813 \]

Estimated GFR (eGFR):

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1. What is the Modified CKD-EPI Equation for Asian Population?

The modified CKD-EPI equation for Asian population estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex with an additional coefficient of 0.813 specifically calibrated for Asian (Japanese) populations. This modification provides more accurate GFR estimation for Asian individuals.

2. How Does the Calculator Work?

The calculator uses the modified CKD-EPI equation for Asian population:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times 0.813 \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( age \) — Age in years
1.018 — Female multiplier
0.813 — Asian population multiplier

Explanation: This equation incorporates population-specific adjustments for Asian individuals, providing more accurate kidney function assessment in this demographic group.

3. Importance of eGFR Calculation for Asian Population

Details: Accurate GFR estimation is crucial for Asian populations due to potential differences in muscle mass, diet, and creatinine metabolism compared to other ethnic groups. The modified equation helps prevent misclassification of kidney disease in Asian individuals.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). The calculator automatically applies the Asian population coefficient of 0.813.

5. Frequently Asked Questions (FAQ)

Q1: Why is a separate equation needed for Asian population?
A: Asian populations may have different muscle mass, dietary patterns, and creatinine metabolism, requiring population-specific calibration for accurate GFR estimation.

Q2: What is the significance of the 0.813 coefficient?
A: The 0.813 coefficient was derived from studies in Japanese populations and adjusts for systematic differences in creatinine generation and excretion in Asian individuals.

Q3: Can this equation be used for all Asian ethnicities?
A: While developed primarily for Japanese population, it is commonly used for various Asian ethnicities, though some regional variations may exist.

Q4: How does this compare to the standard CKD-EPI equation?
A: The Asian-modified equation typically gives slightly lower eGFR values compared to the standard equation, reflecting more accurate estimation for Asian individuals.

Q5: Are there limitations to this equation?
A: As with all estimation equations, it may be less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function.