eGFR Calculated Using CKD EPI

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is eGFR Calculated Using CKD EPI?

eGFR calculated using CKD EPI (Chronic Kidney Disease Epidemiology Collaboration) provides an estimated glomerular filtration rate based on serum creatinine, age, and gender. This equation offers improved accuracy in assessing kidney function compared to previous estimation methods.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation models the non-linear relationship between serum creatinine and glomerular filtration rate, with gender-specific coefficients for optimal accuracy.

3. Importance Of eGFR Calculation

Details: Accurate eGFR estimation is essential for detecting chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What Are The Key Differences In This Equation?
A: This version uses coefficients of 142, -1.200, and 0.9938 with a female multiplier of 1.012, providing refined estimation parameters.

Q2: What Is Considered Normal eGFR Range?
A: Normal eGFR is typically ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² persisting for three months indicate chronic kidney disease.

Q3: When Is The Best Time To Measure Creatinine?
A: Fasting morning samples are preferred, though random samples are acceptable. Avoid testing after high-protein meals or intense physical activity.

Q4: What Are The Limitations Of This Equation?
A: Accuracy may be reduced in extreme age groups, pregnant women, individuals with amputations, or those with rapidly changing kidney function.

Q5: Can This Be Used For Medication Dosing?
A: While useful for screening, precise drug dosing may require measured GFR in specific clinical situations or high-risk populations.