eGFR CKD EPI Calculation

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What Is The eGFR CKD EPI Calculation?

The eGFR CKD EPI (Chronic Kidney Disease Epidemiology Collaboration) calculation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This equation provides an accurate assessment of kidney function for clinical evaluation and monitoring.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation models the non-linear relationship between serum creatinine and glomerular filtration rate, with optimized coefficients for different demographic groups.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, determining appropriate treatment strategies, and adjusting medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between Various eGFR Equations?
A: Different equations (CKD-EPI, MDRD) use varying coefficients and population data. CKD-EPI generally provides better accuracy across a wider range of GFR values.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is typically ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² persisting for 3+ months indicate chronic kidney disease.

Q3: When Should Serum Creatinine Be Measured?
A: Morning fasting samples are preferred, though random samples are acceptable. Avoid testing shortly after high-protein meals or intense physical activity.

Q4: Are There Limitations To This Equation?
A: Accuracy may be reduced in extreme age groups, individuals with unusual muscle mass, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Can This Calculator Be Used For Drug Dosing?
A: While useful for estimation, precise drug dosing may require measured GFR in specific clinical situations or high-risk populations.