What Is eGFR Calculated

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is eGFR Calculated?

eGFR (estimated Glomerular Filtration Rate) Calculated refers to the estimation of kidney function using the CKD-EPI 2021 equation based on serum creatinine, age, and gender. This updated equation provides improved accuracy in assessing kidney function across different populations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation calculates estimated glomerular filtration rate using CKD-EPI 2021 methodology, providing a more refined assessment of kidney function with updated coefficients.

3. Importance of eGFR Calculation

Details: Accurate eGFR calculation is essential for detecting early kidney disease, monitoring kidney function over time, and guiding clinical decisions regarding medication dosing and treatment plans.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is the CKD-EPI 2021 equation?
A: The CKD-EPI 2021 equation is an updated version that provides improved accuracy in estimating glomerular filtration rate compared to previous equations.

Q2: How does this differ from older equations?
A: This version uses updated coefficients (142, -1.200, 0.9938) and refined gender adjustments for better accuracy across diverse populations.

Q3: What are the clinical applications of eGFR?
A: eGFR is used for chronic kidney disease staging, drug dosing adjustments, and monitoring kidney function in various clinical conditions.

Q4: Are there limitations to this calculation?
A: Like all estimation equations, it may be less accurate in extreme age groups, pregnant women, and individuals with unusual muscle mass or diet.

Q5: When should eGFR be interpreted with caution?
A: Caution is needed in rapidly changing kidney function, amputees, severe malnutrition, or when using medications that affect creatinine levels.