What Is Used to Calculate eGFR

eGFR Calculation Formula:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is Used to Calculate eGFR?

This calculator estimates glomerular filtration rate (GFR) using serum creatinine, age, and sex. The equation provides an accurate assessment of kidney function based on these key clinical parameters.

2. How Does the Calculator Work?

The calculator uses the following equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( Age \) — Age in years
1.012 — Female multiplier

Explanation: The equation accounts for the non-linear relationship between creatinine levels and glomerular filtration rate, with specific coefficients adjusted for gender differences.

3. Importance of eGFR Calculation

Details: Accurate estimation of glomerular filtration rate is essential for detecting kidney dysfunction, staging chronic kidney disease, and determining appropriate medication dosages based on renal function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What parameters are used to calculate eGFR?
A: This calculator uses serum creatinine level, age, and gender to estimate glomerular filtration rate.

Q2: Why are different coefficients used for males and females?
A: Gender-specific coefficients account for differences in muscle mass and creatinine production between males and females.

Q3: What is the significance of the age factor?
A: The age factor (0.9938^Age) accounts for the natural decline in kidney function that occurs with aging.

Q4: How accurate is this eGFR calculation?
A: This equation provides a reliable estimate of kidney function for most adult populations, though individual variations may occur.

Q5: When should eGFR be calculated?
A: eGFR should be calculated when assessing kidney function, screening for kidney disease, or adjusting medications that are cleared by the kidneys.