What Is Needed to Calculate eGFR

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is Needed to Calculate eGFR

To calculate eGFR using the CKD-EPI equation, you need three essential parameters: serum creatinine (Scr), age, and sex. These variables are incorporated into the equation to estimate glomerular filtration rate, which reflects kidney function.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The equation accounts for the non-linear relationship between creatinine and GFR, with different coefficients for males and females to provide accurate kidney function estimation.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and guiding appropriate treatment decisions and medication adjustments.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What parameters are needed for eGFR calculation?
A: You need serum creatinine level, age, and sex to calculate eGFR using the CKD-EPI equation.

Q2: Why are different coefficients used for males and females?
A: Males and females have different muscle mass and creatinine production rates, requiring gender-specific coefficients for accurate GFR estimation.

Q3: Is age an important factor in eGFR calculation?
A: Yes, kidney function naturally declines with age, so age is a critical variable in the equation.

Q4: What units should serum creatinine be in?
A: Serum creatinine should be in mg/dL for this calculator. If using different units, conversion is necessary.

Q5: Can this calculator be used for all populations?
A: This version is optimized for non-black populations. For black individuals, additional race adjustment factors may be needed.