What is GFR Calculation CKD EPI

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is GFR Calculation CKD EPI?

Explains GFR calculation using CKD-EPI. The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. It provides a more accurate assessment of kidney function than older equations, especially at higher GFR levels.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The equation accounts for non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing. The eGFR value represents the estimated glomerular filtration rate in mL/min/1.73m².

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). The calculator will provide the estimated GFR based on the CKD-EPI equation parameters.

5. Frequently Asked Questions (FAQ)

Q1: What is the significance of the different coefficients?
A: The coefficients κ and α vary by gender to account for physiological differences in muscle mass and creatinine production between males and females.

Q2: What are normal eGFR values?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.

Q3: Why is the age factor 0.9938?
A: This factor accounts for the natural decline in kidney function that occurs with aging, approximately 1% per year after age 40.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function or unusual muscle mass.

Q5: How does this differ from other GFR equations?
A: This version of CKD-EPI uses slightly different coefficients (142, -1.200, 0.9938) compared to other variants, providing optimized accuracy for specific populations.