What is GFR Calculated MDRD

MDRD Equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is GFR Calculated MDRD?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses power functions to model the inverse relationship between serum creatinine and GFR, with adjustments for demographic factors that influence muscle mass and creatinine production.

3. Importance of MDRD Equation

Details: The MDRD equation revolutionized kidney function assessment by providing a standardized method for estimating GFR from routinely available laboratory data, enabling earlier detection and staging of chronic kidney disease.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120). The calculator provides eGFR in mL/min/1.73m².

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate in patients with established CKD, while CKD-EPI performs better at higher GFR levels and is less likely to misclassify individuals with normal or mildly reduced kidney function.

Q2: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 based on data from the Modification of Diet in Renal Disease study.

Q3: What are the limitations of the MDRD equation?
A: Less accurate in healthy individuals, elderly patients, extremes of body size, and populations not represented in the original study cohort.

Q4: Is MDRD still used clinically?
A: While many laboratories have transitioned to CKD-EPI, MDRD remains in use and is still valuable for tracking kidney function over time in established CKD patients.

Q5: How does race affect the MDRD calculation?
A: The race multiplier accounts for observed differences in muscle mass and creatinine generation between Black and non-Black populations.