What is GFR Calculated Abbreviated MDRD

Abbreviated MDRD Equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What is GFR Calculated Abbreviated MDRD?

The Abbreviated MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It is widely used in clinical practice for assessing kidney function and detecting chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the Abbreviated MDRD equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses serum creatinine levels adjusted for age, gender, and race to estimate kidney filtration rate, providing a standardized assessment of renal function.

3. Importance of eGFR Calculation

Details: eGFR calculation is essential for diagnosing and staging chronic kidney disease, monitoring disease progression, and guiding treatment decisions including medication dosing adjustments.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What does the abbreviated MDRD calculated GFR mean in blood tests?
A: It represents an estimated glomerular filtration rate calculated using the abbreviated MDRD formula, which helps assess how well your kidneys are filtering waste from your blood.

Q2: How accurate is the MDRD equation?
A: The MDRD equation is reasonably accurate for most patients with chronic kidney disease, though it may be less precise at higher GFR levels (>60 mL/min/1.73m²).

Q3: What are the limitations of the MDRD equation?
A: Limitations include reduced accuracy in elderly patients, those with extreme body sizes, pregnant women, and populations with different muscle mass than the original study cohort.

Q4: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 from the Modification of Diet in Renal Disease study and later abbreviated for clinical use.

Q5: Should MDRD be used for all patient populations?
A: While widely used, it may not be ideal for all populations. Some guidelines now recommend CKD-EPI equation as it performs better at higher GFR levels.