What Is GFR Calculated Abbreviated MDRD in Blood Test

Abbreviated MDRD Equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What Is GFR Calculated Abbreviated MDRD in Blood Test?

The Abbreviated MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It provides a standardized method for assessing kidney function and is commonly used in clinical practice for detecting and monitoring chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the Abbreviated MDRD equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses serum creatinine levels adjusted for age, gender, and race to estimate kidney filtration rate, with lower values indicating reduced kidney function.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease stages, monitoring disease progression, and adjusting medication dosages for drugs excreted by the kidneys.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What does GFR calculated by MDRD mean in blood test results?
A: It represents an estimated glomerular filtration rate calculated using the MDRD equation, indicating how well your kidneys are filtering waste from your blood.

Q2: How does MDRD differ from CKD-EPI equation?
A: MDRD tends to underestimate GFR in healthy individuals and is less accurate at higher GFR levels compared to the newer CKD-EPI equation.

Q3: What are the limitations of the MDRD equation?
A: Less accurate in elderly populations, extremes of body size, pregnant women, and those with normal or near-normal kidney function.

Q4: When is MDRD equation most appropriate?
A: Most useful for patients with established chronic kidney disease (GFR < 60 mL/min/1.73m²) and for monitoring disease progression.

Q5: How often should eGFR be monitored?
A: Frequency depends on clinical context - typically every 3-12 months for stable CKD patients, more frequently during acute illness or medication changes.