What Is GFR Calculated Abbreviated MDRD Test

Abbreviated MDRD Equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What Is GFR Calculated Abbreviated MDRD Test?

The Abbreviated MDRD (Modification of Diet in Renal Disease) Study equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a standardized method for assessing kidney function in patients with chronic kidney disease.

2. How Does The Calculator Work?

The calculator uses the Abbreviated MDRD equation:

\[ eGFR = 175 \times Scr^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses serum creatinine, age, gender, and race to estimate kidney function, with different coefficients accounting for demographic variations in creatinine production.

3. Importance Of eGFR Calculation

Details: The MDRD equation is widely used for detecting and staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on kidney function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120). The result provides estimated GFR in mL/min/1.73m².

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between MDRD And CKD-EPI Equations?
A: MDRD is more accurate in patients with established kidney disease, while CKD-EPI performs better at higher GFR levels and is less likely to over-diagnose CKD in healthy individuals.

Q2: When Was The MDRD Equation Developed?
A: The MDRD Study was conducted in the 1990s, with the abbreviated version published in 2000 to simplify clinical use while maintaining accuracy.

Q3: What Are The Limitations Of The MDRD Equation?
A: Less accurate in elderly patients, those with normal kidney function, pregnant women, and populations with extreme body composition.

Q4: Why Include Race In The Equation?
A: Race accounts for differences in muscle mass and creatinine generation between populations, though this practice is being re-evaluated in modern medicine.

Q5: Is MDRD Suitable For All Patient Populations?
A: While widely used, it may not be optimal for children, transplant recipients, or patients with rapidly changing kidney function where measured GFR is preferred.