What Is GFR CKD-EPI Calc

GFR CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is GFR CKD-EPI Calc?

GFR CKD-EPI (Glomerular Filtration Rate Chronic Kidney Disease Epidemiology Collaboration) calculation estimates kidney function from serum creatinine, age, and sex. It provides accurate assessment of glomerular filtration rate for clinical evaluation of kidney health.

2. How Does The Calculator Work?

The calculator uses the GFR CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation calculates estimated glomerular filtration rate based on serum creatinine levels adjusted for age and gender differences in muscle mass and creatinine production.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for detecting kidney impairment, monitoring kidney disease progression, and making informed clinical decisions about patient management and treatment.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid with creatinine greater than 0 and age between 1-120 years for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What Does GFR CKD-EPI Calculate?
A: It calculates estimated glomerular filtration rate, which measures how well kidneys filter waste from blood, using serum creatinine, age, and gender.

Q2: How Accurate Is This Calculation?
A: GFR CKD-EPI provides reliable estimates for most adult populations and is widely used in clinical practice for kidney function assessment.

Q3: When Should This Calculation Be Used?
A: Use for routine kidney function screening, monitoring known kidney disease, and before procedures or medications that affect kidney function.

Q4: What Are The Limitations?
A: Less accurate in extremes of age, muscle mass variations, pregnancy, and rapidly changing kidney function. Not suitable for children.

Q5: How Often Should GFR Be Calculated?
A: Frequency depends on clinical context - annually for screening, more frequently for known kidney disease or when monitoring specific treatments.