1. What is the NKF Pediatric GFR Equation?

The National Kidney Foundation (NKF) pediatric GFR equation estimates glomerular filtration rate in children using height and serum creatinine. This simplified formula provides a reliable estimate of kidney function specifically validated for pediatric populations.

2. How Does the Calculator Work?

The calculator uses the NKF pediatric GFR equation:

Where:

• \( Height \) — Patient height in centimeters (cm)
• \( Scr \) — Serum creatinine in milligrams per deciliter (mg/dL)
• 0.413 — Empirical coefficient derived from pediatric population studies

Explanation: This equation leverages the strong correlation between height and muscle mass in children, providing a more accurate GFR estimation than adult formulas.

3. Importance of Pediatric GFR Calculation

Details: Accurate GFR estimation in children is essential for detecting congenital kidney abnormalities, monitoring chronic kidney disease progression, and adjusting medication dosages for pediatric patients.

4. Using the Calculator

Tips: Enter height in centimeters and serum creatinine in mg/dL. Ensure measurements are recent and accurate. The equation is validated for children aged 1-18 years.

5. Frequently Asked Questions (FAQ)

Q1: What age range is this equation valid for?
A: The NKF pediatric GFR equation is validated for children aged 1-18 years. For infants under 1 year, specialized neonatal equations should be used.

Q2: Why use height instead of age in pediatric GFR calculation?
A: Height correlates better with muscle mass and body surface area in growing children, providing more stable GFR estimates across different developmental stages.

Q3: What are normal eGFR values for children?
A: Normal pediatric eGFR values are generally higher than adults, typically ranging from 90-140 mL/min/1.73m², varying by age and body size.

Q4: Are there limitations to this equation?
A: This equation may be less accurate in children with extreme body habitus, malnutrition, edema, or rapidly changing kidney function.

Q5: How often should GFR be monitored in children with kidney disease?
A: Monitoring frequency depends on the underlying condition, but typically every 3-6 months for stable chronic kidney disease, and more frequently during acute illness or treatment changes.