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Pediatric GFR using CKiD cystatin C equation:
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The Pediatric GFR Cystatin C equation, developed by the CKiD (Chronic Kidney Disease in Children) study, estimates glomerular filtration rate (GFR) in pediatric patients using serum cystatin C levels. This equation provides a reliable assessment of kidney function in children without the need for height measurements.
The calculator uses the CKiD cystatin C equation:
Where:
Explanation: The equation uses the inverse relationship between serum cystatin C and glomerular filtration rate, specifically calibrated for pediatric patients.
Details: Accurate GFR estimation in children is essential for diagnosing and monitoring chronic kidney disease, adjusting medication doses, and assessing kidney function in various pediatric conditions.
Tips: Enter serum cystatin C in mg/L. The value must be greater than 0. This calculator is specifically designed for pediatric patients.
Q1: What age range is this equation valid for?
A: This equation is validated for children and adolescents, typically from 1 to 18 years of age.
Q2: Why use cystatin C instead of creatinine in children?
A: Cystatin C is less influenced by muscle mass, making it more reliable in children where muscle mass varies significantly with age and development.
Q3: What are normal eGFR values in children?
A: Normal pediatric eGFR values vary by age and body size, but generally range from 90-140 mL/min/1.73m² in healthy children.
Q4: Are there limitations to this equation?
A: This equation may be less accurate in children with extreme body composition, severe malnutrition, or certain medical conditions affecting cystatin C metabolism.
Q5: Can this be used for drug dosing in children?
A: While useful for estimating kidney function, consult specific pediatric dosing guidelines and consider measured GFR for critical medications.