1. What is the UK Paediatric GFR Equation?

The UK Paediatric GFR equation is specifically designed for estimating glomerular filtration rate in children. It uses height and serum creatinine to provide an accurate assessment of kidney function in paediatric populations, accounting for the unique physiological characteristics of growing children.

2. How Does the Calculator Work?

The calculator uses the UK Paediatric GFR equation:

Where:

• \( Height \) — Height in centimeters (cm)
• \( Scr \) — Serum creatinine in milligrams per deciliter (mg/dL)
• 0.413 — Empirical constant derived from paediatric population studies

Explanation: This equation accounts for the relationship between body size (height) and creatinine metabolism in children, providing a more accurate GFR estimation than adult equations.

3. Importance of Paediatric GFR Calculation

Details: Accurate GFR estimation in children is essential for diagnosing kidney diseases, monitoring treatment response, adjusting medication doses, and assessing growth and development impacts on renal function.

4. Using the Calculator

Tips: Enter height in centimeters and serum creatinine in mg/dL. Ensure measurements are recent and accurate. The equation is validated for use in children and adolescents.

5. Frequently Asked Questions (FAQ)

Q1: What age range is this equation suitable for?
A: This equation is specifically designed for paediatric patients, typically from infancy through adolescence.

Q2: Why is height used instead of weight in this equation?
A: Height provides a more stable and reliable measure of body size in growing children and correlates well with muscle mass and creatinine production.

Q3: What are normal eGFR values for children?
A: Normal eGFR values in children vary by age and body size, but generally range from 90-140 mL/min/1.73m², with higher values in younger children.

Q4: Are there limitations to this equation?
A: This equation may be less accurate in children with extreme body habitus, malnutrition, or rapidly changing kidney function.

Q5: Can this equation be used for drug dosing in children?
A: While useful for general assessment, specific drug dosing in children with kidney impairment should be guided by measured GFR and clinical consultation.