National Kidney Disease GFR Calculator

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the National Kidney Disease GFR Calculator?

The National Kidney Disease GFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy for kidney function assessment across diverse populations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The 2021 CKD-EPI equation incorporates updated coefficients based on more recent population data, providing enhanced accuracy in GFR estimation.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What's new in the CKD-EPI 2021 equation?
A: The 2021 version uses updated coefficients (142, -1.200, 0.9938) and refined gender adjustments based on contemporary population data.

Q2: How does this differ from previous CKD-EPI equations?
A: The 2021 equation provides improved calibration and better performance across different age groups and kidney function levels.

Q3: What are the clinical applications of this calculator?
A: Used for CKD screening, staging, monitoring disease progression, and adjusting medication dosages based on kidney function.

Q4: Are there population limitations?
A: While validated across diverse populations, caution is advised in extremes of age, body composition, and certain ethnic groups.

Q5: When should confirmatory testing be considered?
A: When eGFR results are inconsistent with clinical presentation or for precise drug dosing in critical medications.