1. What is the NIDDK Pediatric eGFR Equation?

The NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) pediatric equation estimates glomerular filtration rate (GFR) specifically for children using height and serum creatinine. This simplified formula is widely used in pediatric nephrology practice.

2. How Does the Calculator Work?

The calculator uses the NIDDK Pediatric equation:

Where:

• \( Height \) — Height in centimeters (cm)
• \( Scr \) — Serum creatinine in milligrams per deciliter (mg/dL)
• 0.413 — Constant coefficient

Explanation: This equation accounts for the relationship between body size (represented by height) and creatinine clearance in pediatric patients, providing a quick and reliable estimate of kidney function.

3. Importance of Pediatric eGFR Calculation

Details: Accurate GFR estimation in children is essential for diagnosing kidney diseases, monitoring treatment response, adjusting medication doses, and assessing growth and development related to kidney function.

4. Using the Calculator

Tips: Enter height in centimeters and serum creatinine in mg/dL. Ensure both values are positive and accurate measurements. This calculator is specifically designed for pediatric patients.

5. Frequently Asked Questions (FAQ)

Q1: What age range is this equation appropriate for?
A: The NIDDK pediatric equation is typically used for children aged 1-18 years. For infants under 1 year, other specialized equations may be more appropriate.

Q2: Why is height used instead of weight in this equation?
A: Height is used as it better correlates with muscle mass and creatinine production in growing children, providing a more stable reference than weight which can fluctuate.

Q3: What are normal eGFR values for children?
A: Normal eGFR values in children vary by age and body size, but generally range from 90-140 mL/min/1.73m². Values should be interpreted in context with age-specific norms.

Q4: Are there limitations to this equation?
A: This equation may be less accurate in children with extreme body habitus, malnutrition, or rapidly changing kidney function. It should be used as a screening tool alongside clinical assessment.

Q5: When should this equation not be used?
A: Avoid using this equation for neonates, children with amputations, those with rapidly changing creatinine levels, or when precise GFR measurement is required for critical decisions.