MedCalc eGFR CKD EPI

MedCalc eGFR using CKD-EPI:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is MedCalc eGFR CKD EPI?

MedCalc eGFR using CKD-EPI estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This implementation uses the MedCalc version of the CKD-EPI equation with specific coefficients optimized for clinical use.

2. How Does the Calculator Work?

The calculator uses the MedCalc CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( Age \) — Age in years
1.012 — Female multiplier

Explanation: This equation provides a refined estimation of kidney function using optimized coefficients from MedCalc's implementation of the CKD-EPI formula.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What makes MedCalc eGFR different from standard CKD-EPI?
A: MedCalc uses slightly different coefficients (142 instead of 141, -1.200 instead of -1.209, etc.) optimized for their clinical calculator platform.

Q2: What are the normal eGFR ranges?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild kidney impairment, while values below 60 for 3+ months suggest chronic kidney disease.

Q3: When is the best time to measure creatinine?
A: Morning fasting samples are preferred, but random samples can be used. Avoid testing after high-protein meals or intense physical activity.

Q4: Are there limitations to this equation?
A: The equation may be less accurate in elderly patients, extremes of body size, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Can this calculator be used for medication dosing?
A: While useful for screening, precise drug dosing may require measured GFR in specific clinical situations or high-risk patients.