MedCalc GFR CKD EPI

MedCalc CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the MedCalc CKD-EPI Equation?

The MedCalc CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version uses optimized coefficients for improved accuracy in clinical practice.

2. How Does the Calculator Work?

The calculator uses the MedCalc CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation provides a refined estimation of kidney function with optimized coefficients for different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, determining disease progression, and guiding appropriate treatment decisions and medication adjustments.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What makes MedCalc CKD-EPI different from standard CKD-EPI?
A: MedCalc version uses refined coefficients (142, -1.200, 0.9938, 1.012) optimized for clinical accuracy across diverse populations.

Q2: What are the reference ranges for eGFR?
A: Normal eGFR is typically ≥90 mL/min/1.73m². Values between 60-89 may indicate mild reduction, while below 60 for 3+ months suggests chronic kidney disease.

Q3: When is the best time to measure serum creatinine?
A: Morning fasting samples are preferred, though random samples are acceptable. Avoid testing after high-protein meals or intense physical activity.

Q4: Are there limitations to this equation?
A: Accuracy may be reduced in extreme age groups, pregnant women, individuals with amputations, or those with rapidly changing kidney function.

Q5: Can this calculator be used for medication dosing?
A: While useful for estimation, precise drug dosing may require measured GFR in specific clinical situations or high-risk populations.