Mayo eGFR Calculator

Mayo Quadratic Equation:

\[ eGFR = \exp(1.911 + \frac{5.249}{Scr} - \frac{2.114}{Scr^2} - 0.00686 \times Age - (0.205 \text{ if female})) \]

Estimated GFR (eGFR):

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1. What is the Mayo Quadratic Equation?

The Mayo Quadratic Equation is an alternative method for estimating glomerular filtration rate (GFR) from serum creatinine, age, and sex. It was developed at the Mayo Clinic and provides a different mathematical approach to GFR estimation compared to other equations.

2. How Does the Calculator Work?

The calculator uses the Mayo Quadratic equation:

\[ eGFR = \exp(1.911 + \frac{5.249}{Scr} - \frac{2.114}{Scr^2} - 0.00686 \times Age - (0.205 \text{ if female})) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.205 — Female adjustment factor

Explanation: The equation uses an exponential function with quadratic terms in the denominator of serum creatinine to model the relationship between creatinine levels and kidney function.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for detecting kidney dysfunction, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: How does Mayo Quadratic differ from CKD-EPI?
A: The Mayo Quadratic uses an exponential function with quadratic terms, while CKD-EPI uses piecewise linear modeling. They may perform differently in specific patient populations.

Q2: When is Mayo Quadratic preferred?
A: This equation may be particularly useful in populations with higher GFR levels or when creatinine values fall within specific ranges where quadratic modeling provides better accuracy.

Q3: What are the limitations of this equation?
A: Like other estimation equations, it may be less accurate in extremes of age, body composition, or in patients with rapidly changing kidney function.

Q4: Does this equation account for race?
A: The standard Mayo Quadratic Equation does not include race as a variable, unlike some other GFR estimation equations.

Q5: How should results be interpreted clinically?
A: Results should be interpreted in the context of clinical presentation, other laboratory findings, and serial measurements for trend analysis.