Liverpool eGFR Calculator

Liverpool CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the Liverpool eGFR Calculator?

The Liverpool eGFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in estimating kidney function across diverse populations.

2. How Does the Calculator Work?

The calculator uses the Liverpool CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation incorporates updated coefficients based on recent research to provide more accurate GFR estimation, particularly in modern clinical populations.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate treatment decisions and medication dosing.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What makes the Liverpool CKD-EPI 2021 equation different?
A: This version uses updated coefficients (142, -1.200, 0.9938) and gender factors based on more recent population data for improved accuracy.

Q2: Why is race not included in this equation?
A: The Liverpool 2021 equation follows modern recommendations to eliminate race-based adjustments, focusing on biological factors only.

Q3: What are the clinical applications of this calculator?
A: Used for CKD screening, monitoring kidney function in chronic diseases, drug dosing adjustments, and pre-operative assessments.

Q4: How does this compare to other eGFR equations?
A: Provides similar accuracy to standard CKD-EPI but with updated coefficients that may better reflect contemporary populations.

Q5: Are there limitations to this equation?
A: Like all creatinine-based equations, it may be less accurate in extremes of age, muscle mass, or in populations with rapidly changing kidney function.