Kidney Foundation eGFR Calculator

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the Kidney Foundation eGFR Calculator?

The Kidney Foundation eGFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in assessing kidney function across diverse populations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This updated equation incorporates refined coefficients based on recent population studies, providing more accurate GFR estimation across different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management and treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What's new in the CKD-EPI 2021 equation?
A: The 2021 update includes refined coefficients based on larger, more diverse population data, improving accuracy across different ethnic groups and age ranges.

Q2: How does this differ from previous CKD-EPI equations?
A: This version uses updated intercept (142 vs 141), different exponents (-1.200 vs -1.209), and refined gender coefficients for improved precision.

Q3: What are the clinical applications of this calculator?
A: Used for CKD screening, staging kidney disease, monitoring kidney function over time, and adjusting medication dosages based on renal function.

Q4: Are there population limitations?
A: While improved, caution is still advised in extremes of age, pregnancy, severe malnutrition, or rapidly changing kidney function.

Q5: How often should eGFR be monitored?
A: Frequency depends on clinical context - annually for high-risk patients, more frequently for those with established kidney disease or changing clinical status.