Kidney Foundation GFR Calculator

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The Kidney Foundation GFR Calculator?

The Kidney Foundation GFR Calculator uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in assessing kidney function across diverse populations.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This updated equation incorporates refined coefficients based on recent population studies, providing more accurate GFR estimation across different demographic groups.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management and medication adjustments.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What's New In The CKD-EPI 2021 Equation?
A: The 2021 update features refined coefficients (142, -1.200, 0.9938) and gender adjustments based on contemporary population data for improved accuracy.

Q2: How Does This Differ From Previous Versions?
A: This version uses updated constants and exponents that better reflect current population characteristics and provide more precise GFR estimates.

Q3: What Are The Clinical Applications?
A: Used for CKD screening, staging, monitoring disease progression, and adjusting drug dosages in patients with renal impairment.

Q4: Are There Population Limitations?
A: While validated across diverse populations, caution is advised in extremes of age, body composition, and certain ethnic groups not well represented in validation studies.

Q5: When Should Direct GFR Measurement Be Considered?
A: Consider direct measurement in patients with unusual muscle mass, amputations, severe obesity, or when highly precise GFR values are clinically necessary.