How to Calculate eGFR in India

CKD-EPI 2021 Equation (India without race factor):

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI 2021 Equation for India?

The CKD-EPI 2021 equation for India estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex without race factor. This updated equation is specifically validated for the Indian population and provides more accurate assessment of kidney function in this demographic.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation for India:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier for Indian population

Explanation: This equation is specifically calibrated for the Indian population and excludes race factor, making it more appropriate for use in India and South Asian populations.

3. Importance of eGFR Calculation in Indian Population

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease in the Indian population, where diabetes and hypertension are prevalent risk factors. The race-free equation eliminates potential bias and provides more equitable healthcare assessment.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator is specifically designed for Indian population without race adjustment.

5. Frequently Asked Questions (FAQ)

Q1: Why use CKD-EPI 2021 for India instead of standard CKD-EPI?
A: The CKD-EPI 2021 equation is specifically validated for Indian population and excludes race factor, providing more accurate results for this demographic.

Q2: Is race factor important in eGFR calculation for Indians?
A: Recent guidelines recommend race-free equations for all populations. The CKD-EPI 2021 for India is designed without race factor specifically for Indian population.

Q3: What are normal eGFR values for Indian adults?
A: Normal is generally ≥90 mL/min/1.73m², though values may vary slightly based on regional and demographic factors within India.

Q4: Are there limitations to this equation for Indian population?
A: While validated for Indian population, individual variations may exist. The equation may be less accurate in extremes of age, body composition, or rapidly changing kidney function.

Q5: Can this calculator be used for other South Asian populations?
A: While specifically validated for Indian population, it may provide reasonable estimates for other South Asian populations, though local validation is recommended.