1. What is GFR from Creatinine?

GFR (Glomerular Filtration Rate) from creatinine is estimated using the CKD-EPI equation, which calculates kidney function based on serum creatinine levels, age, and gender. This provides a reliable assessment of renal filtration capacity.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( \kappa \) — 0.7 (female) or 0.9 (male)
• \( \alpha \) — -0.241 (female) or -0.302 (male)
• \( age \) — Age in years
• 1.012 — Female multiplier

Explanation: The equation models the inverse relationship between serum creatinine and glomerular filtration rate, with gender-specific coefficients for improved accuracy.

3. Importance of GFR Calculation

Details: GFR estimation is essential for detecting kidney dysfunction, monitoring disease progression, and adjusting medication dosages based on renal clearance.

4. Using the Calculator

Tips: Input serum creatinine in mg/dL, age in years, and select gender. Ensure creatinine values are positive and age is within reasonable range (1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the normal range for GFR?
A: Normal GFR is typically ≥90 mL/min/1.73m². Values below 60 sustained for 3+ months indicate chronic kidney disease.

Q2: Why are different coefficients used for males and females?
A: Muscle mass differences affect creatinine production, requiring gender-specific adjustments for accurate GFR estimation.

Q3: When is the best time to measure creatinine?
A: Fasting morning samples are preferred, but random samples are acceptable. Avoid testing after high-protein meals or intense physical activity.

Q4: What factors can affect GFR accuracy?
A: Extreme age, muscle wasting, amputations, pregnancy, and rapidly changing kidney function can reduce equation accuracy.

Q5: Can this calculator be used for medication dosing?
A: While useful for screening, precise drug dosing may require measured GFR in specific clinical situations.