How Is eGFR Calculated UK

UK eGFR Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the UK eGFR Equation?

The UK eGFR equation is a modified version used in the United Kingdom to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This equation is specifically calibrated for the UK population and provides accurate assessment of kidney function.

2. How Does the Calculator Work?

The calculator uses the UK eGFR equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{Age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( Age \) — Age in years
1.012 — Female multiplier

Explanation: This equation accounts for the non-linear relationship between creatinine and GFR, with specific coefficients optimized for the UK population demographics.

3. Importance of eGFR Calculation in UK

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease in the UK population, determining disease stage according to NICE guidelines, and guiding appropriate clinical management and medication dosing.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator follows UK clinical practice standards.

5. Frequently Asked Questions (FAQ)

Q1: How does the UK equation differ from CKD-EPI?
A: The UK equation uses different coefficients (142 vs 141, -1.200 vs -1.209, 0.9938 vs 0.993) and is specifically calibrated for the UK population.

Q2: What are the NICE guidelines for eGFR interpretation in UK?
A: NICE guidelines classify CKD stages based on eGFR: Stage 1 (≥90), Stage 2 (60-89), Stage 3a (45-59), Stage 3b (30-44), Stage 4 (15-29), Stage 5 (<15).

Q3: Is race adjustment used in the UK equation?
A: No, the UK equation does not include race adjustment factors, unlike some other international equations.

Q4: When should eGFR be measured in UK clinical practice?
A: According to UK guidelines, eGFR should be measured in patients with hypertension, diabetes, cardiovascular disease, or those at risk of kidney disease.

Q5: Are there age-specific considerations for eGFR in UK?
A: Yes, eGFR naturally declines with age. In elderly patients, additional clinical assessment is recommended alongside eGFR values.