GFR Calculator in AKI

GFR Equation for AKI:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the GFR Calculator in AKI?

This calculator estimates glomerular filtration rate (GFR) in acute kidney injury (AKI) using a modified CKD-EPI equation. While CKD-EPI is primarily designed for chronic kidney disease assessment, this adaptation provides GFR estimation in acute settings.

2. How Does the Calculator Work?

The calculator uses the AKI GFR equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation modifies the standard CKD-EPI formula with adjusted coefficients for acute kidney injury scenarios.

3. Importance of GFR Calculation in AKI

Details: GFR estimation in acute kidney injury is crucial for assessing the severity of renal impairment, guiding fluid management, and adjusting medication dosages in critically ill patients.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). Note that this is an estimation tool and not ideal for precise AKI management.

5. Frequently Asked Questions (FAQ)

Q1: Is this calculator ideal for AKI management?
A: No, this calculator uses CKD-EPI adaptation and is not ideal for precise AKI management. Direct GFR measurement methods are preferred in acute settings.

Q2: What are the limitations in AKI?
A: In AKI, serum creatinine may not reflect true GFR due to rapidly changing renal function, fluid shifts, and other acute factors.

Q3: When should this calculator be used in AKI?
A: For initial assessment and trend monitoring, but clinical judgment and direct measurements should guide critical decisions.

Q4: How does AKI differ from CKD in GFR estimation?
A: AKI involves rapid changes in kidney function, making estimation equations less reliable compared to stable CKD conditions.

Q5: What are better alternatives for AKI?
A: Measured GFR using clearance methods (iohexol, inulin) or dynamic monitoring provides more accurate assessment in acute kidney injury.