GFR Calculator for Infants

Schwartz Equation for Term Infants:

\[ eGFR = 0.45 \times \frac{Height}{Scr} \]

Estimated GFR (eGFR):

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1. What is the Schwartz Equation for Infants?

The Schwartz equation is specifically designed for estimating glomerular filtration rate (GFR) in term infants. It uses height and serum creatinine to provide a reliable assessment of kidney function in this pediatric population.

2. How Does the Calculator Work?

The calculator uses the Schwartz equation for term infants:

\[ eGFR = 0.45 \times \frac{Height}{Scr} \]

Where:

\( Height \) — Infant height in centimeters (cm)
\( Scr \) — Serum creatinine in milligrams per deciliter (mg/dL)
0.45 — Empirical constant for term infants

Explanation: This simplified equation accounts for the relationship between body size (represented by height) and creatinine clearance in infants, providing a practical tool for clinical assessment.

3. Importance of Infant GFR Calculation

Details: Accurate GFR estimation in infants is crucial for detecting congenital kidney abnormalities, monitoring kidney function in critically ill neonates, and guiding medication dosing in this vulnerable population.

4. Using the Calculator

Tips: Enter infant height in centimeters and serum creatinine in mg/dL. Ensure measurements are recent and accurate. Height should be measured lying down for infants.

5. Frequently Asked Questions (FAQ)

Q1: What age range is this equation valid for?
A: This equation is specifically validated for term infants, typically from birth up to 12 months of age.

Q2: How does this differ from the standard Schwartz equation?
A: The standard Schwartz equation uses a constant of 0.413 for children, while this version uses 0.45 specifically optimized for term infants.

Q3: What are normal eGFR values for infants?
A: Normal GFR in term infants ranges from 30-50 mL/min/1.73m² at birth, increasing to adult levels by 1-2 years of age.

Q4: Are there limitations to this equation?
A: This equation may be less accurate in preterm infants, infants with severe malnutrition, or those with rapidly changing kidney function.

Q5: When should creatinine be measured in infants?
A: Creatinine should be measured when there's clinical concern for kidney dysfunction, before nephrotoxic medications, or when monitoring known kidney conditions.