GFR Calculator Using CKD-EPI

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The GFR Calculator Using CKD-EPI?

The GFR Calculator Using CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) 2021 equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated version provides improved accuracy in estimating kidney function across diverse populations.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The CKD-EPI 2021 equation incorporates updated coefficients based on more recent population data, providing enhanced accuracy in GFR estimation without race adjustment.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, determining appropriate medication dosages, and assessing overall kidney health.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What Is New In The CKD-EPI 2021 Equation?
A: The CKD-EPI 2021 equation features updated coefficients (142, -1.200, 0.9938) and removes race adjustment, providing a more universally applicable GFR estimation formula.

Q2: How Does CKD-EPI 2021 Compare To Previous Versions?
A: The 2021 version demonstrates improved accuracy across diverse populations and eliminates race-based adjustments, aligning with current medical consensus.

Q3: What Are Normal eGFR Values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild kidney impairment, while values below 60 for 3+ months suggest chronic kidney disease.

Q4: When Should Creatinine Be Measured?
A: Morning fasting samples are preferred, but random samples are acceptable. Avoid testing immediately after high-protein meals or intense physical activity.

Q5: Are There Limitations To This Equation?
A: The equation may be less accurate in extreme age groups, pregnant women, individuals with amputations, severe malnutrition, or rapidly changing kidney function.