GFR Calculation CKD EPI 95

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI Creatinine Equation?

The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This specific version targets calculations around 95 mL/min/1.73m² for enhanced accuracy in this range.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation variant is optimized for GFR calculations around 95 mL/min/1.73m², providing improved accuracy in this specific range.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation around 95 mL/min/1.73m² is crucial for early detection of kidney function changes and monitoring borderline cases where kidney function may be transitioning from normal to mildly impaired.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. This calculator is specifically calibrated for optimal performance when eGFR results are around 95 mL/min/1.73m².

5. Frequently Asked Questions (FAQ)

Q1: Why is this version optimized for 95 mL/min/1.73m²?
A: This specific parameterization provides enhanced accuracy in the borderline range between normal kidney function and early stage CKD.

Q2: What makes this equation different from standard CKD-EPI?
A: It uses modified coefficients (142, -1.200, 0.9938, 1.012) specifically calibrated for improved performance around 95 mL/min/1.73m².

Q3: When is this calculator most useful?
A: Ideal for patients with borderline kidney function, monitoring treatment response, and research studies focusing on early kidney disease detection.

Q4: Are there limitations to this specific equation?
A: While optimized for the 95 mL/min/1.73m² range, it may be less accurate at extreme GFR values compared to the standard CKD-EPI equation.

Q5: Should race adjustment be considered?
A: This version does not include race adjustment factors, focusing specifically on the gender and age parameters for the target range.