GFR Calculation CKD EPI 120

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The GFR Calculation CKD EPI 120?

The GFR Calculation CKD EPI 120 is a specialized version of the CKD-EPI equation that estimates glomerular filtration rate (GFR) with coefficients optimized for values around 120 mL/min/1.73m². It provides accurate kidney function assessment using serum creatinine, age, and gender.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 120 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for eGFR values around 120 mL/min/1.73m², providing enhanced accuracy in this range while maintaining the robust CKD-EPI framework.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation around 120 mL/min/1.73m² is particularly important for early detection of kidney function changes in healthy individuals and for monitoring kidney health in populations with normal to high-normal kidney function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. This calculator is optimized for eGFR values around 120 mL/min/1.73m². All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: Why Use This Specific CKD-EPI Variant?
A: This version is optimized for eGFR values around 120 mL/min/1.73m², providing superior accuracy in this range compared to standard CKD-EPI equations.

Q2: What Populations Benefit Most From This Calculation?
A: Young healthy adults, athletes, and individuals with normal kidney function where precise measurement around 120 mL/min/1.73m² is clinically relevant.

Q3: How Does This Differ From Standard CKD-EPI?
A: It uses different coefficients (142 base, -1.200 exponent, 0.9938 age factor) specifically calibrated for the 120 mL/min/1.73m² range.

Q4: When Is This Calculation Most Useful?
A: For routine health screenings, pre-operative assessments, and monitoring kidney function in populations expected to have normal to high-normal GFR values.

Q5: Are There Limitations To This Equation?
A: While optimized for ~120 mL/min/1.73m², it may be less accurate at extreme GFR values. Always consider clinical context and confirm with additional testing when needed.