GFR Calculation CKD EPI 106

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The GFR Calculation CKD EPI 106?

The GFR Calculation CKD EPI 106 uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in estimating kidney function compared to previous versions.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation represents the latest CKD-EPI formulation with updated coefficients for improved accuracy across different population groups.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate treatment strategies and medication dosages.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between CKD-EPI 2021 And Previous Versions?
A: The CKD-EPI 2021 equation uses updated coefficients (142 instead of 141, different alpha values, and 0.9938 instead of 0.993) for improved accuracy.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild kidney impairment, while values below 60 for 3+ months indicate chronic kidney disease.

Q3: When Should Creatinine Be Measured?
A: Morning fasting samples are preferred, but random samples are acceptable. Avoid testing after consuming large amounts of meat or engaging in strenuous exercise.

Q4: Are There Limitations To This Equation?
A: The equation may be less accurate in elderly patients, those with extreme body weights, amputees, pregnant women, and individuals with rapidly changing kidney function.

Q5: Can This Calculator Be Used For Drug Dosing?
A: While useful for estimating kidney function, for precise drug dosing in critical situations, measured GFR methods may be required.