GFR Calculation CKD EPI 104

CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The GFR Calculation CKD EPI 104?

The GFR Calculation CKD EPI 104 is a specific variant of the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version uses optimized coefficients for improved accuracy in certain populations.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 104 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation provides a refined estimation of kidney function using specific coefficients that have been validated in clinical studies.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are within valid ranges (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What Makes CKD EPI 104 Different From Standard CKD-EPI?
A: CKD EPI 104 uses specific coefficients (142, -1.200, 0.9938, 1.012) that have been optimized for particular patient populations and study cohorts.

Q2: What Are The Clinical Applications Of This Equation?
A: This equation is used for accurate GFR estimation in adult populations, particularly in research settings and specialized clinical practice.

Q3: Are There Any Limitations To This Specific Equation?
A: Like other estimation equations, it may be less accurate in extreme age groups, pregnant women, and individuals with unusual body composition.

Q4: How Often Should eGFR Be Calculated?
A: Frequency depends on clinical context - annually for screening, more frequently for monitoring known kidney disease or during medication changes.

Q5: Can This Equation Be Used For Children?
A: No, this equation is validated for adults only. Pediatric GFR estimation requires specialized equations.