GFR Calcolo CKD EPI eGFR

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI 2021 Equation?

The CKD-EPI 2021 equation is an updated version that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This Italian version provides improved accuracy for GFR estimation in European populations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This updated equation uses refined coefficients optimized for better accuracy in European populations, particularly in Italian demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What's new in the CKD-EPI 2021 equation?
A: The 2021 version features updated coefficients (142, -1.200, 0.9938) and gender-specific parameters optimized for European populations.

Q2: Why is this version specific for Italian population?
A: The coefficients were derived and validated using Italian cohort data, providing better accuracy for this demographic group.

Q3: What are normal eGFR values?
A: Normal GFR is generally ≥90 mL/min/1.73m². Values below 60 sustained for 3+ months indicate chronic kidney disease.

Q4: Are there limitations to this equation?
A: Like all estimation equations, it may be less accurate in extremes of age, body composition, and in populations with rapidly changing kidney function.

Q5: Can this calculator be used for clinical decisions?
A: This tool provides estimates for educational purposes. Clinical decisions should be made by healthcare professionals using comprehensive patient evaluation.